I am currently on methotrexate and haven’t drank at all. I’ve been on it since February. I may be switching off of this medication due to the fact that I’m suffering too much from the side effects (fatigue and nausea, to be exact). I’m just wondering how long I should continue to abstain until I know the methotrexate won’t interfere if I have a glass of wine or something like that.

Answer by Borovich
Long half life so at least 2 months.