Toxic dose or lethal dose of furosemide. Cant seem to be to discover this in the net or my books. All i can find in the net is the toxic dose of furosemide for animals.
Solution by Fritzkreig
The acute toxicity of furosemide has been determined in mice, rats and dogs. In all three, the oral LD50 exceeded 1000 mg/kg physique excess weight although the intravenous LD50 ranged from 300 to 680 mg/kg. The acute intragastric toxicity in neonatal rats is 7 to ten occasions that of adult rats.
From what I understand the use of mice, rats, and dogs gives a very good base and ball park figure for humans. Obviously a scientific experiment with people would be unethical so all we have to go on are the anecdotal instances which have a lot ofextraneouss variables although evenanalysiss and meta analysis on over doses in humans nearly usually help the estimate that was determined in animals. So 50% of human adults will die at 1000 mg/kg body weight orally and 300 to 680 mg/kg intravenously.Hope it will help!